Anti-SIRPα antibodies, including multispecific anti-SIRPα antibodies, are provided as well as related compositions and methods. The antibodies of the present disclosure can bind to SIRPα and block the interaction of SIRPα on phagocytic cells with CD47 on one cell. [Selection diagram] Fig. 3多重特異性抗SIRPα抗体を含む抗SIRPα抗体を、関連する組成物及び方法と同様に、提供する。本開示の抗体は、SIRPαに結合し、食細胞上のSIRPαと1つの細胞上のCD47との相互作用を遮断することができる。【選択図】図3