A novel fibrinogen based tissue adhesive patch is disclosed. The patch comprises a backing made from a non permeable biocompatible polymer film into which a fibrinogen based sealant is incorporated. In preferred embodiments of the invention the fibrinogen based sealant comprises fibrinogen thrombin and CaCl. The polymer backing serves to seal the tissue to which the patch is applied and the sealant acts only to bind the patch to the affected tissue. The patch does not include any mesh or woven component. Methods of production of the patch are also disclosed.
