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TRICYCLISCHE N-HETEROARYL-CARBOXAMID-DERIVATE SOWIE DEREN HERSTELLUNG UND THERAPEUTISCHE ANWENDUNG
专利权人:
SANOFI
发明人:
DUBOIS, LAURENT,EVANNO, YANNICK,MALANDA, ANDRÉ
申请号:
EP08839139.6
公开号:
EP2185558B1
申请日:
2008.07.31
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
Tricyclic N-heteroaryl carboxamide derivatives (I) and their acid or base addition salts, hydrates or solvates are new. Tricyclic N-heteroaryl carboxamide derivatives of formula (I) and their acid or base addition salts, hydrates or solvates are new. A : bicycle to which it is merged with Z 2-Z 3, 4-7C cycloalkyl group, monocyclic heterocyclic ring or monocyclic heteroaryl of 4-7 membered ring having 1-3 heteroatoms of O, S or N, including Z 2-Z 3atoms; either Z 1, Z 5-Z 8 : N, C or a C-R 2; and Z 1-Z 9 : form bicyclic heteroaryl linked to N atom of amide or thioamide of (I), where the positions of Z 5-Z 8are correspond to C, and the positions of Z 4-Z 9are correspond to N; W 1 : O or S; P 1 : indolyl, pyrrolo[2,3-c]pyridinyl, pyrrolo[2,3-b]pyridinyl, pyrrolo[3,2-b]pyridinyl, pyrrolo[3,2-c]pyridinyl linked in position C-2 at carbonyl of amide or thiocarbonyl of thioamide of (I) or indole derivative of formula (a); X 1-X 4 : N or C-R 1group (where other three is C-R 1group when one of X 1, X 2, X 3or X 4is N); R 1 : H, halo, 1-6C alkyl, 3-7C cycloalkyl, 3-7C-cycloalkyl-1-3C-alkylene, 1-6C-fluoroalkyl, aryloxy-1-6C-alkyl, heteroaryloxy-1-6C-alkyl, aryl-1-3C-alkylenoxy-1-6C-alkyl, heteroaryl-1-3C-alkylenoxy-1-6C-alkyl, arylthio-1-6C-alkyl, heteroarylthio-1-6C-alkyl, aryl-1-3C-alkylene-thio-1-6C-alkyl, heteroaryl-1-3C-alkylene-thio-1-6C-alkyl, 1-6C-alkoxy, 3-7C-cycloalkyloxy, 3-7C-cycloalkyl-1-3C-alkylenoxy, 1-6C-fluoroalkoxy, CN, C(O)NR 4R 5, N, NR 4R 5, 1-6C-thioalkyl, 3-7C-cycloalkylthio, 3-7C-cycloalkyl-1-3C-alkylene-thio, -S(O)-1-6C-alkyl, -S(O)-3-7C-cycloalkyl, -S(O)-1-3C-alkylene-3-7C-cycloalkyl, 1-6C-alkyl-S(O) 2-, 1-6C-fluoroalkyl-S(O) 2-, 3-7C-cycloalkyl-S(O) 2-, 3-7-cycloalkyl-1-3C-alkylene-S(O) 2-, SO 2NR 4R 5, SF 5, NR 6C(O)R 7, NR 6SO 2R 8, C(O)NR 4R 5, OC(O)NR 4R 5, aryl, heteroaryl, aryl-1-5C-alkylene, heteroaryl-1-5C-alkylene, aryloxy, arylthio, heteroaryloxy or heteroarylthio, heteroaryl or aryl groups (optionally substituted by R 9); n : 0.1, 2 or 3;
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http://www.ckcest.cn/home/
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