INTRA-ARTICULAR INJECTION AND IMPLANT ATTACHMENT OF MOLECULE CONSISTING OF LUBRICIN AND EXTRACELLULAR SUPEROXIDE DISMUTASE OR HYALURONIC ACID AND EXTRACELLULAR SUPEROXIDE DISMUTASE
Brandon L. Roller,Christopher M. Bare,Tithi Dutta Roy,Ricardo Albertorio
申请号：
US14323692
公开号：
US20150010606A1
申请日:
2014.07.03
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Formulations, mixtures, compositions and techniques for improved treatment options for osteoarthritis and intra-articular joint degeneration. The formulations and compositions are provided in the form of injectable aqueous formulations that increase the delivery of a lubricating agent (lubrication molecules) into the joint to resist breakdown, decrease free radical production (by neutralizing these radicals), and increase removal of superoxide byproducts in the synovial fluid. The injectable aqueous formulations are preferably administered into the intra-articular space of an intra-articular joint. The lubricating formulation includes molecules of lubricin and SOD, hyaluronic acid and SOD, or lubricin and SOD and hyaluronic acid, or hyaluronic acid and lubricin, or Vitamin E and SOD or hyaluronic acid, or combinations thereof.
