Disclosed is a general formula (I), which are cyclically substituted 4-phenyl-pyridine derivatives, or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof wherein: x is 2 Ra is H or methyl R1 is selected from the group consisting of: carbocyclic or -alkyl-carbocyclic, wherein the carbocyclic group is cyclohexyl or cyclopentyl heterocyclic or -alkyl-heterocyclic group, wherein the heterocyclic group is piperidine, piperazine, morpholine or pyrrolidine aryl or -alkyl-aryl heteroaryl or -alkyl-heteroaryl, wherein the heteroaryl group is pyridine, thiazole or thiophene wherein any of the aforesaid carbocyclic, heterocyclic, aryl or heteroaryl groups may optionally be substituted each R2 is independently R4, -alkyl-R4, OR4, NHR4, -NHalkyl-R4, -O-alkyl-R4, SR4, SOR4 or SO2R4 wherein R4 is a carbocyclic or heterocyclic group any of which may be further substituted wherein the remaining substituents are as defined herein and wherein any of the aforesaid carbocyclic groups and heterocyclic groups may be saturated or partially unsaturated, but do not include aromatic rings or non-aromatic rings fused to aromatic rings. Wherein, the specifically disclosed compounds of the specification are all as claimed in the granted parent patent.
