The Board of Trustees of The Leland Stanford Junior University
发明人:
CHAN, Charles K. F.,WEISSMAN, Irving L.,LONGAKER, Michael T.
申请号：
EP16735360
公开号：
EP3242934A4
申请日:
2016.01.06
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
Methods, compositions and kits for producing functional chondrocytes, skeletal cells, bone marrow stromal cells, and progenitor cells thereof are provided. These methods, compositions and kits find use in producing chondrocytes, osteoblasts, stromal cells, and progenitor cells thereof in vivo, or in vitro for transplantation, for experimental evaluation, as a source of lineage- and cell-specific products, and the like, for example for use in treating human disorders of the cartilage, bone and hematopoietic system. In some embodiments, specific combinations of protein factors are identified for reprogramming non-skeletal cells into bones, hematopoietic stroma, and chondrocytes, which may be provided in vitro or in vivo.
