GIORDANI, Antonio,BIAVA, Mariangela,ANZINI, Maurizio,CALDERONE, Vincenzo,ROVATI, Lucio Claudio
申请号：
ES11768129
公开号：
ES2568253T3
申请日:
2011.09.07
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
Compound of formula (I), a solvate thereof or pharmaceutically acceptable salt: ** Formula ** in which: - the substituent in position 1 of the pyrrole ring is a phenyl, substituted at the meta and para positions with R 'groups and R "independently selected from: hydrogen (-H), fluorine (-F), chlorine (-Cl), bromine (-Br), methyl (-CH3), trifluoromethyl (-CF3), methoxy (-OCH3), thiomethyl (-SCH3)； - the R1 substituent is independently selected from the following groups: methyl (-CH3), ethyl (-C2H5), trifluoromethyl (-CF3), hydroxymethyl (-CH2OH), methoxymethyl (-CH2OCH3)； - the substituent in position -3 of the pyrrole ring is a chain, in which the groups X, Y, Z, W and R2 have the following meanings: X is selected from the groups: carbonyl - (C>； = O) -, - ( CHR3) - in which R3 is as defined hereinbelow； and is selected from an oxygen atom (-O-) or the group -NR3- in which R3 is as defined below in this document to； Z is selected from a carbonyl - (C>； = O) -, a group - (CHR3) -, a group [-CH (COOH) -] or a group - (NR3) - in which R3 is as It is defined later in this document； W is a saturated aliphatic chain with 1 to 3 carbon atoms, linear or branched, substituted with one or two nitro ester groups (-O-NO2)； R2 is independently selected from the groups: hydrogen (-H), hydroxyl (-OH), methoxy (-OCH3) or amino (-NHR3)； wherein in the above-mentioned groups in which R3 is present, the R3 groups may be identical or different and are independently selected from: hydrogen (-H), methyl (-CH3), ethyl (-CH2CH3), isopropyl [- CH2 (CH3) 2]； the group R '"is independently selected from: methylsulfonyl (-SO2Me) and sulfonamido (-SO2NH2)； provided that: - when X is a group C>； = O and Y is an oxygen atom (-O-), Z does not it is a carbonyl group (C>； = O)； - when X is a group - (CHR3) -, Y is not a group - (CHR3) -； including the individual enantiomers of the compounds of formula (I) in the form ( R) or (S), the respective racemic mixtures and enriched mixtures with sai
