Systems and methods for the insertion of bone screws and for fluid injection using bone screws are described. A bone screw used for fluid injection includes a screw body with a central passage extending at least partially into the screw body and defining an inlet end which includes an opening configured to matingly receive therein an injector tip of a fluid injector. The screw body includes a number of fluid flow passages extending through the screw body wall such as to direct fluid in an outward direction from within the central passage, through the screw body, and into the tissue site surrounding the screw. Another bone screw which is inserted using a guide wire includes a cannulated passage having a non-circular cross-section configured to rotationally interconnect the guide wire such that relative axial rotation between the guide wire and the bone screw is prevented.
