An method and system for supplemental gas delivery that enables the identification of a need of therapeutic attention for patient receiving the supplemental gas (20) by detecting an onset of an exacerbation of a medical condition. Such a detection is performed by detecting audible events using a microphone (60) that is in fluid communication with a cannula (28) that is used to communicate the supplemental gas (20) with the airways of the patient (8). The audible event may be, for instance, a cough in the patient. A change in the relative frequency of coughs in the patient may be identified by the routines as being indicative of an onset of an exacerbation.