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Tamper resistant controlled release dosage forms
专利权人:
Purdue Pharma L.P.
发明人:
Haiyong Hugh Huang
申请号:
US15045977
公开号:
US09872837B2
申请日:
2016.02.17
申请国别(地区):
US
年份:
2018
代理人:
摘要:
In certain embodiments, the present invention is directed to a solid controlled release dosage form comprising: a core comprising a first portion of an opioid analgesic dispersed in a first matrix material; and a shell encasing the core and comprising a second portion of the opioid analgesic dispersed in a second matrix material; wherein the amount of opioid analgesic released from the dosage form is proportional within 20% to elapsed time from 8 to 24 hours, as measured by an in-vitro dissolution in a USP Apparatus 1 (basket) at 100 rpm in 900 ml simulated gastric fluid without enzymes (SGF) at 37 C.
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