Manmohan Singh,David A. G. Skibinksi,Tom Yao-Hsiang Wu,Yongkai Li,Alex Cortez,Xiaoyue Zhang,Yefen Zou,Timothy Z. Hoffman,Jianfeng Pan,Kathy Yue
申请号：
US15093652
公开号：
US10098949B2
申请日:
2016.04.07
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Immunopotentiators can be adsorbed to insoluble metal salts, such as aluminum salts, to modify their pharmacokinetics, pharmacodynamics, intramuscular retention time, and/or immunostimulatory effect. Immunopotentiators are modified to introduce a moiety, such as a phosphonate group, which can mediate adsorption. These modified compounds can retain or improve their in vivo immunological activity even when delivered in an adsorbed form.
