The present invention relates to an antibody-drug-conjugate capable of binding IGF-lR. From one aspect, the invention relates to an antibody-drug-conjugate comprising an antibody capable of binding to IGF-lR, said antibody being conjugated to at least one drug selected from derivatives of dolastatin 10 and auristatins. The invention also comprises method of treatment and the use of said antibody-drug- conjugate for the treatment of cancer.