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Method and Composition for Treating Gastro-Esophageal Disorders
专利权人:
Ismail Gurol;Robert Burns;Steven Loyd;George Blouin
发明人:
Ismail Gurol,Robert Burns,Steven Loyd,George Blouin
申请号:
US15583791
公开号:
US20170232036A1
申请日:
2017.05.01
申请国别(地区):
US
年份:
2017
代理人:
摘要:
An orally administered composition that includes least one alkaline agent with a pH of at least 9.0 to 12.0, mixed in an aqueous vehicle with relatively high surface tension, high viscosity and lateral adhesion properties. When mixed, a low water soluble emulsion is formed that evenly coats and partially adheres to the lower section of the esophagus and the LES and forms a relatively long acting, protective barrier and partially neutralizes gastric acid. Mixed in the composition is at least one catechin 0.01 to 0.05% by weight. The alkaline agent is potassium hydroxide and the aqueous vehicle is made of hydroxypropyl methyl cellulose, polyethylene glycol or ethylene glycol and additional thickener agents capable of withstanding high pH environments, such as xanthan gum, croscarmellose sodium, and microcrystalline cellulose. Additional organoleptic agents, such as gum Arabic and polyethylene glycol, flavorings, such as sodium chloride, acesulfame potassium, sodium saccharine, and mint, and stabilizers such as colloidal silica made be added.
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