The Board of Trustees of the Leland Stanford Junior University;U.S. Government as represented by the Department of Veterans Affairs;The Regents of the University of California;Alkahest, Inc.
#$%^&*AU2020210181A120200813.pdf#####ABSTRACT Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include reducing the p2-microglobulin (B2M) level in the mammal in a manner sufficient to treat the mammal for the agingassociated impairment. A variety of aging-associated impairments may be treated by practice of the methods, which impairments include cognitive impairments.