The United States of America; as represented by the Secretary; Department of Health and Human Services
发明人:
Kwong, Peter,Graham, Barney,Mascola, John,Ou, Li,Druz, Aliaksandr,Chen, Man,Kong, Wing-Pui,Georgiev, Ivelin Stefanov,Rundlet, Emily,Joyce, Michael Gordon,Tsybovsky, Yaroslav,Thomas, Paul,Pancera, Mari
申请号：
AU2017242020
公开号：
AU2017242020A1
申请日:
2017.03.29
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
Embodiments of a recombinant Respiratory Syncytial Virus (RSV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the RSV F ectodomain trimer and methods of producing the RSV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the recombinant RSV F ectodomain trimer to the subject.
