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DICLOFENAC BASED COMPOSITIONS
专利权人:
ФЕРРИНГ Б.В. (NL)
发明人:
ГРЕНЬЕ Арно (FR),КАРРАРА Дарио Н. (CH)
申请号:
RU2014152445
公开号:
RU2014152445A
申请日:
2013.07.04
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. Transdermal or transmucosal composition containing: - at least 3 mass. % diclofenac, - С-С-alkanol, - polyalcohol and monoalkyl ether of diethylene glycol; and at least 3 mass. % fatty alcohol. 2. A transdermal or transmucosal composition according to claim 1, further comprising at least one of the following: a gelling agent, an antioxidant and a solvent, or any combination thereof. 3. The composition of claim 1, wherein the alkanol is present in an amount of about 5-60 wt. %, polyalcohol is present in an amount of about 1-30 mass. %, diethylene glycol monoalkyl ether is present in an amount of about 0.2-25 wt. %, fatty alcohol is present in an amount of about 3-5 mass. %, a gelling agent is present in an amount of about 0.05-5 wt. %, and the antioxidant is present in an amount of about 0.025-2.0 mass. %.four. The composition of claim 1, wherein the alkanol is selected from one or more than one of the group consisting of ethanol, isopropanol, n-propanol, butan-1-ol and butan-2-ol. The composition of claim 4, wherein the alkanol is ethanol. 6. The composition of claim 5, wherein ethanol is present in an amount of about 45.0 mass. % .7. A composition according to claim 1, wherein the polyalcohol is selected from one or more than one of the group consisting of ethylene glycol, propylene glycol, butylene glycol and hexylene glycol. The composition of claim 7, wherein the polyalcohol is propylene glycol. The composition of claim 8, wherein the polyalcohol is propylene glycol present in an amount of about 20.0 mass. %.10. A composition according to claim 1, wherein one or both of diethylene glycol monoethyl ether and diethylene glycol monomethyl ether are present as diethylene glycol monoalkyl ether. The composition of claim 10, wherein diethylene glycol monoethyl ether is present in1. Трансдермальная или трансмукозальная композиция, содержащая:- по меньшей мере 3 масс. % диклофенака,- С-С-алканол,- полиспирт и- простой моноалкиловый эфир диэтиленгликоля; и- по меньшей
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中国工程科技知识中心
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