The invention relates to an activating mechanism for a medicament delivery device (1), comprising: - an outer body (8), - a cartridge (2) containing a dosage of a medicament and sealed with a sealing element (2.1) that is arranged across an open distal end of the cartridge (2), - a cartridge carrier (4) adapted to hold the cartridge (2), - a needle safety mechanism adapted to hold a double-ended hollow needle (6) and to relatively move along a longitudinal axis (L) with respect to the cartridge (2) and to the outer body (8) to cover or to expose the needle (6), - wherein in an initial position (P1) of the medicament delivery device (1), the double-ended hollow needle (6) is spaced from the cartridge (2) in a distal direction (D), and - wherein when the needle safety mechanism is pressed into the outer body (8), a proximal end of the needle (6) pierces the sealing element (2.1). The invention further relates to a medicament delivery device (1) comprising such an activating mechanism.本發明有關於一種用於藥物傳輸裝置(1)的致動機構，該致動機構包括：一外主體(8)；一藥筒(2)，該藥筒(2)容納有一定劑量的藥物並且用一密封元件(2.1）密封，該密封元件(2.1)橫跨該藥筒(2)的一開放遠端配置；一藥筒載體(4)，該藥筒載體(4)適於保持該藥筒(2)；一針安全機構，該針安全機構適於保持一雙頭中空針(6)並且適於相對於該藥筒(2)以及相對於該外主體(8)沿一縱軸線(L)相對地移動，以覆蓋或露出該針(6)，其中，在該藥物傳輸裝置(1)的一初始位置(P1)中，該雙頭中空針(6)在一遠側方向(D)上與該藥筒(2)隔開，並且其中，當該針安全機構被壓入到該外主體(8)中時，該針(6)的一近端刺穿該密封元件(2.1)。本發明進一步有關於一種包括這種致動機構的藥物傳輸裝置(1)。
