PROCÉDÉS DE PRODUCTION DE CELLULES SOUCHES RÉTINIENNES DE MAMMIFÈRE ET LEURS UTILISATIONS

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专利权人:

The Regents of the University of California

发明人:

申请号：

EP14852550.4

公开号：

EP3047017A4

申请日:

2014.10.09

申请国别(地区):

EP

年份:

2017

代理人:

摘要：

The invention provides an in vitro method for producing isolated mammalian primitive retinal stem cells (pRSCs) comprising: (a) culturing isolated embryonic stem cells (ESCs) from a mammal in a cell culture medium that is free of feeder cells, feeder-conditioned medium or serum so as to produce and grow a culture of the isolated ESCs； and (b) contacting the culture of the isolated ESCs so grown with one or more of an inhibitor for Wnt or TGF-β/BMP signaling so as to differentiate the isolated ESCs of (a) into primitive retinal stem cells thereby producing isolated mammalian pRSCs.

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