Materials, formulations, production methods and methods are provided to manage the RNM of CFTR to induce CFTR performance, including in mamifero's lungs. The current invention is particularly useful for the treatment of cystic fibrosisSe proporcionan materiales, formulaciones, metodos de produccion, y metodos para la administracion del ARNm de CFTR para la induccion de la expresion de CFTR, incluido en los pulmones de mamifero. La presente invencion es particularmente util para tratar la fibrosis quistica
