A stimulation and sensing system may be configured to deliver an electrical signal to a patient and sense a response from one or more acupuncture points of the patient. The sensed response may be analyzed to detect a health state of the patient by evaluating a condition or property of the patient's meridian system. The electrodes may include noninvasive electrodes and/or percutaneous electrodes such as non-insulated and/or partially insulated acupuncture needles.