МАТАРУ Амол (US),ТЕЛЛАРДА Аньес (CH),ВАГНЕР Роберт Франк (US)
申请号：
RU2010139567/15
公开号：
RU2010139567A
申请日:
2009.02.27
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. A method of obtaining a pharmaceutical formulation of MR-type valsartan, which consists in the fact that (a) a mixture is prepared by combining valsartan, a hydrophobic component and optionally a hydrophilic component； and (b) compressing the mixture to obtain a solid oral dosage form in the form of a tablet. ! 2. The method according to claim 1, in which the solid oral dosage form is a tablet. ! 3. The method according to claim 1, wherein the optionally present sizing agent is further mixed with the mixture before compressing the mixture to form a tablet. ! 4. The method according to claim 1, where the method is carried out in practically anhydrous conditions. ! 5. The method according to claim 1, wherein the hydrophilic decomposable component is selected from the group consisting of hydroxypropyl methyl cellulose, lactose, croscarmellose sodium, polyvinyl pyrrolidone, guar and xanthan gum, polyethylene glycol (MM>； 400), various types of cellulose, hydroxymethyl cellulose, hydroxymethyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose, sodium salt of carboxymethyl cellulose, sodium alginate, methyl cellulose, carboxypolymethylene, gum arabic, tragacanth gum and polyethylene xid. ! 6. The method according to claim 7, in which the hydrophilic capable of disintegrating component is hydroxypropylmethyl cellulose. ! 7. The method according to claim 1, in which the hydrophobic component is selected from the group comprising ethyl cellulose, polymers and copolymers of methacrylic acid, fatty acids and their esters, waxes and high molecular weight fatty alcohols. ! 8. The method according to claim 1, in which the hydrophobic component is selected from the group comprising EUDRAGIT NE 30 D, manufactured by Rohm and1. Способ получения фармацевтической препаративной формы MR-типа валсартана, заключающийся в том, что (а) приготавливают смесь путем объединения валсартана, гидрофобного компонента и необязательно гидрофильного компонента； и (б) прессуют смесь с по
