A small gauge mechanical tissue cutter/aspirator probe usefulfor removing the trabecular meshwork of a human eye has a generallycylindricalouter cannula, an inner cannula that reciprocates in the outer cannula,a port located near or at the distal end of the outer cannula on a side or tipofthe outer cannula, and a guide with a distal surface located on the distal endof the outer cannula. A distance between the distal surface of the guide andthe port is approximately equal to the distance between the back wall ofSchlemm's canal and the trabecular meshwork.