Kug C. Kim;Byungchul Shin;Seo Y. Kim;In-Gyu Kim;Min J. Kim;So Y. Lee
发明人:
In-Gyu Kim,Byungchul Shin,Kug C. Kim,Seo Y. Kim,Min J. Kim,So Y. Lee
申请号：
US14116981
公开号：
US20140147423A1
申请日:
2011.12.22
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to fibulin-3 protein and a pharmaceutical composition comprising the fibulin-3 protein as an active ingredient for inhibiting the growth of cancer stem cells. More particularly, in cancer stem cells separated from H460 and A549 cells, which are non-small-cell lung cancer cells, using ALDH1 activity as a marker, fibulin-3 induces the reductions of wnt/β-catenin, MMP2 and 7, which display characteristics of cancer stem cells, thereby decreasing the activated growth and penetration of the cancer stem cells. In addition, the purified fibulin-3 protein inhibits the growth of the non-small-cell lung cancer cell line A549, the breast cancer cell line MDA-MB231, and the cancer stem cell line active ALDH1. Therefore, fibulin-3 can be valuably used as an active ingredient of the pharmaceutical composition for inhibiting the growth of cancer stem cells.
