TLR AGONISTS FOR REDUCING ACTIVATION-INDUCED PD-1 EXPRESSION ON T CELLS AND METHODS OF USE

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专利权人:

发明人:

Douglas G. McNeel,Christopher D. Zahm

申请号：

US15838824

公开号：

US20180169224A1

申请日:

2017.12.12

申请国别(地区):

US

年份:

2018

代理人:

摘要：

The present invention is directed toward methods of increasing the immune response to an antigen using TLR1/2 agonist and/or TLR7 agonist in combination with a T cell activating treatment, for example, a vaccine. In some aspects, the present invention provides methods of enhancing an anti-tumor response comprising administering at least one TLR1/2 agonist and/or at least one TLR7 agonist in combination with an immunotherapeutic agent.

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