The present invention provides certain quinazoline compounds, its composition and its application methods. These quinazoline compounds can effectively inhibit the overexpression and/or overactivity of EGF-R ELISA (EGFR).本發明提供了某些喹唑啉化合物、其組合物及其使用方法。這些喹唑啉化合物能有效地抑制表皮生長因子受體(EGFR)的過量表達和/或過度活性。