PITTARELLO MARA,ZANELLATO ANNA MARIA,GAMBILLARA ANTONIO,VACCARO SUSANNA
申请号：
IN4623/KOLNP/2007
公开号：
IN262295B
申请日:
2007.11.29
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
Process for the preparation of phosphatidylserine of formula CH2OR1 CHOR2 CH2O-P(=O)-OCH2-CH(NH2)-COOH X wherein R1 and R2 independently represent a saturated, mono-unsaturated or polyunsaturated acyl C10-C30, X=OH or OM where M=alkaline or alkaline earth metal, ammonium, alkylammonium (including the inner salt) including the transphosphatidylation reaction between phosphatidylcholine of the general formula CH2OR1 CHOR2 CH2O-P(=O)-OR3 X wherein R1 and R2 and X have the above specified meanings, R3 =CH2-CH2- NH2 or CH2-CH2-N+ (CH3)3 and Serine in D, L or racemic form catalysed by the phospholipase D enzyme (PLD), characterised in that said reaction is carried out in a hydroalcoholic medium containing an aliphatic alcohol and in the presence of bivalent metal oxide.
