A disinfecting and pre-opening device is disclosed for use with a female needleless connector. The disinfecting and pre-opening device includes a housing comprising a chamber having a distal opening and configured to fit over the female needleless connector, and an elongated finger attached to the housing and disposed within the chamber such that the elongated finger opens the fluid path through the female needleless connector when the distal opening of the disinfecting and pre-opening device is placed proximally adjacent to the septum and the disinfecting and pre-opening device is advanced in the distal direction.本發明係揭示一種與一母無針式連接器一起使用的消毒與預開裝置。該消毒與預開裝置包含一殼體,該殼體包括一具一遠端開口且被構型成裝配於母無針式連接器的腔室,及一被連接至該殼體且置於該腔室內之長形指狀物,而致使該消毒與預開裝置之遠端開口被置在近側上鄰近於該隔板,且消毒與預開裝置係在該遠端方向上前進時,該長形指狀物打開經過該母針式連接器之流體路徑。40‧‧‧母魯爾(Luer)連接器42‧‧‧螺紋44‧‧‧彈性體隔板46‧‧‧切口48‧‧‧近端表面50‧‧‧消毒和預開裝置52‧‧‧殼體53‧‧‧腔室54‧‧‧螺紋55‧‧‧周圍側壁56‧‧‧基材57‧‧‧近端壁58‧‧‧中央指狀物