Boehringer Ingelheim International GmbH;Boehringer Ingelheim Pharma GmbH & Co. KG
发明人:
TRUNK, Michael,WEILER, Claudius,PIEROTH, Werner
申请号：
EP07847111.7
公开号：
EP2094240B1
申请日:
2007.11.06
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
Spray-dried powder formulation (Q) comprises particles comprising components of (a) hydroxy-di-thiophen-2-yl-acetic acid (4R,5S,7S)-9,9-dimethyl-3-oxa-9-aza-tricyclo[3.3.1.02,4]non-7-yl ester compound (I)； (b) at least one embedding material of mono or disaccharides, oligosaccharides, polymers, sugar alcohols or cholesterol； and (c) an organic, physiologically acceptable, sterically demanding acid of ascorbic acid, a fruit or culinary acid and mono, di or trivalent carbonic acid with exception of amino carboxylic acids. Spray-dried powder formulation (Q) comprises particles comprising components of (a) hydroxy-di-thiophen-2-yl-acetic acid (4R,5S,7S)-9,9-dimethyl-3-oxa-9-aza-tricyclo[3.3.1.0(2,4)]non-7-yl ester compound of formula (I)； (b) at least one embedding material of mono or disaccharides, oligosaccharides, polymers, sugar alcohols or cholesterol； and (c) an organic, physiologically acceptable, sterically demanding acid of ascorbic acid, a fruit or culinary acid and mono, di- or trivalent carbonic acid with exception of amino carboxylic acids. X ->；a negatively charged anion, preferably chloride, bromide (preferred), iodide, sulfate, phosphate, methanesulfonate, nitrate, maleate, acetate, citrate, fumarate, tartrate, oxalate, succinate, benzoate or p-toluenesulfonate. An independent claim is included for a method for preparing (Q) containing particles comprising providing a solution of components (a)-(c) in a suitable solvent, spraying the solution in a hot air current, drying the sprayed solution to form a powder containing particle and separating the powder by cyclone or filter. [Image] [Image] ACTIVITY : Respiratory-Gen； Antiasthmatic. No biological data given. MECHANISM OF ACTION : None given.
