BATTERIK Liza E. (US),БАТТЭРИК Лиза Э. (US),KANNINGEM Skott D. (US),КАННИНГЭМ Скотт Д. (US),DIKOSIMO Robert (US),ДИКОСИМО Роберт (US),FOSSER Kari E. (US),ФОССЕР Кари Э. (US),GRUBER Tanya Mariya (US),Г,BATTERIK Liza E.,БАТТЭРИК Лиза Э.,KANNINGEM Skott D.,КАННИНГЭМ Скотт Д.,DIKOSIMO Robert,ДИКОСИМО Роберт,FOSSER Kari E.,ФОССЕР Кари Э.,GRUBER Tanya Mariya,ГРУБЕР Таня Мария,KHEJNI Sheron L.,ХЕЙНИ Шерон
申请号：
RU2013133831
公开号：
RU0002660373C2
申请日:
2011.12.19
申请国别(地区):
RU
年份:
2018
代理人:
摘要：
FIELD: hygiene.SUBSTANCE: group of inventions relates to the field of personal care products intended for oral treatment with a peracid agent, a method for preparing such an agent and a perhydrolytic enzyme in the form of a fusion protein for preparation thereof. Peracid is obtained from a substrate using an enzyme catalyst in the form of a fusion protein having perhydrolytic activity in the presence of a source of peroxygen. Said fusion protein comprises the following general structure: PAH-[L]y-OCBD or OCBD-[L]y-PAH, where PAH is an enzyme having perhydrolytic activity, and is a carbohydrate esterase having a signature motif CE-7 that aligns with the reference sequence SEQ ID NO: 2 and contains: 1) the RGQ motif at positions corresponding to positions 118-120 of SEQ ID NO: 2； 2) the GXSQG motif at positions corresponding to positions 179-183 of SEQ ID NO: 2, and 3) the HE motif in positions corresponding to positions 298-299 of SEQ ID NO: 2； OCBD is a peptide component having an affinity for the surface of the oral cavity, and is an antibody from a single-stranded variable fragment (scFv) or a single-stranded polypeptide without immunoglobulin folding； L is an optional peptide linker with a length in the range of 1 to 100 amino acids； and y is 0 or 1. Oral care product comprises said fusion protein, at least one carboxylic acid ester substrate, a peroxygen source and an oral acceptable carrier medium.EFFECT: peracid beneficial agent can be used for clarification, bleaching, decontamination, discolouration, deodorisation, reduction and/or removal of biofilm from the surface of the oral cavity, while the use of the above-mentioned fusion protein provides for "targeting" perhydrolytic activity to the surface of the oral cavity.13 cl, 25 tbl, 17 exГруппа изобретений относится к области продуктов для личной гигиены, предназначенных для обработки полости рта перкислотным средством, способу получения такого средства и пергидролитическому ферменту в форме гибридного белка
