1. This list refers to N - [4 - (1H pirazolo [3, 4-b] pirazin-6-il) - phenyl] - sulfur amide. Formula compound (1) is an active pharmacological compound used to regulate the activity of a quinase protein, especially the activity of quinase controlled by serum and glucose poisoning (SGK),In particular, kunoza 1 regulated by serum and glucose poisoning (sgk-1, SGK1) is suitable for the treatment of diseases with insufficient SGK activity, such as degenerative disorders or inflammation of joints, such as arthritis or rheumatism. Program for formulation compounds (1),It is used in medicine and the synthesis of medicine containing these substances. 1. Claim 1: a formula compound (1),a. Any form of stereoisomer, or any proportion of stereoisomer mixture, or pharmaceutically acceptable salts, AR is selected from phenyl series and monocyclic aromatic heterocycle, consisting of 5 to 6 members and 1 member； Two or three identical or different cyclic atoms, consisting of nitrogen, oxygen and sulfur, and cyclic carbon atoms, all of which are replaced or not replaced by one or more identical or different r1830404； n is selected from the series consisting of 0, 1 and 2；R1 is n (R1) - R2 selected from the hydrogen series,-N (R) -C (O) -R-N (R1 m3) - S (o) 8322090；-N (R1 m3) - C (o) - nh-r1-r8308；-C (O) -N (R) -R-CN - c833218a, 83318324y - c833218a, 8324318a - o-r1831222；R² is selected from the series consisting of halogen, -C₁₋₄ alkyl,-O-codilo c8321e.83318324y-cn； r1830404 was selected from the halogen series, Aquilo c8321e.83248331；-C₃₋₇ cycloalkyl,-C₁₋₄ alkyl-C₃₋₇ cycloalkyl,-O-C₁₋₄-alkyl,-O-C₃₋₇- cycloalkyl,-O-C₁₋₄-C₃₋₇ -cycloalkyl alkyl,-N (R) -R-N (R) -N (R) -R-N (R) -C (O) -R-No.8322；-C (o) - n (R n) (R 8308y-cn) and two r83044 groups are connected with the adjacent ar ring carbon atoms. Together with the carbon atoms supporting them, a ring composed of five unsaturated rings and eight atoms is formed. The ring consists of the same or different ring atoms. It is compose
