An apparatus and method for predicting a parameter in the blood stream of a subject is disclosed. The apparatus comprises a laser diode source arranged to emit light of at least two different wavelength a first optical receiver arranged to receive incident light of the two different wavelength where the subject is not present a second optical receiver arranged to receive transmitted or diffuse reflected light of the two different wavelength when a desired part of the subject is present and a processor for calculating the ratio of the intensity of the received transmitted or diffuse reflected light to incident light for each of the at least two different wavelengths to provide an indication of the parameter in the blood stream of the subject. The apparatus and method are particularly suited for measuring HbA1c in an individual.係揭示一種用於預測個體之血流中一參數的裝置及方法。該裝置包含一雷射二級體光源,配置為可發出至少兩種不同波長之光線;一第一光學接收器,配置為可接收該至少二不同波長之入射光,其中該個體不存在;一第二光學接收器,配置為可接收該至少二不同波長之穿透光,當希望之個體部分存在時;以及一處理器,用以計算該至少二不同波長之每一者之接收穿透光或擴散反射光強度比入射光強度之比例,以提供該個體血流中之一參數指標。該裝置與方法特別適用於測量個體中之HbA1c。10...裝置12...個體14...雷射二級體光源14a、14b...雷射二級體光源16...第一光學接收器18...第二光學接收器20...處理器22...影像偵測器24...影像偵測器26...數據庫30...光纖