SMITH, ALEXANDER,WHITE, HANNAH S.,ANDRES, PATRICIA,SUN, XUFENG,ZHU, LEI,VLAHOVA, PETINKA I.
申请号：
CA3067873
公开号：
CA3067873A1
申请日:
2018.06.29
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
This invention provides an unexpectedly stable, highly crystalline form of the di-HCl salt of 2'-((5-(4-isopropylpiperazin-l-yl)pyridin-2-yl)amino)-7',8'-dihydro-6'H-spiro[cyclohexane-1,9'-pyrazino[1'2':1'5]pyrrolo[2,3-d]pyrimidin]-6'-one for advantageous therapeutic pharmaceutical efficacy and dosage form stability.
