This invention provides a uracil derivative of general formula (I) or its physiologically acceptable salts: (wherein R1 represents a hydrogen atom, a C1-10 alkyl group, a C2-6 alkenyl group or a 3- to 6-membered saturated or 4- to 6-membered unsaturated alicyclic group which may contain 1 to 2 hetero atoms selected from a group consisting of N, O and S； R2 represents a hydrogen atom, a halogen atom, a cyano group, -NRcRd, -N=CHN(CH3)2 or a C1-3 alkyl group； Ar1and Ar2, each independently represents a 5-to 6-membered aromatic cyclic group which may contain 1 to 3 hetero atoms selected from a group consisting of N, O and S； L represents a 6-membered aromatic cyclic group which may contain 1 to 4 nitrogen atoms, pyrazole, triazole or imidazole)； and a therapeutic or prophylactic agent for various elastase-involved inflammatory diseases containing the compound and so on as active ingredient.本發明提供下述通式(I)所示之尿嘧啶衍生物或其生理上容許之鹽：(式中，R1表示氫原子、C1-10烷基、C2-6烯基、或可含有選自N、O及S所組成之群組之1至2個雜原子之3至6員飽和或4至6員不飽和之脂肪族環基；R2表示氫原子、鹵素原子、氰基、-NRcRd、-N=CHN(CH3)2或C1-3烷基；Ar1及Ar2各自獨立，表示可含有選自N、O及S所組成之群組之1至3個雜原子之5至6員芳香族環基；L表示可含有1至4個氮原子之6員芳香族環基、吡唑、三唑或咪唑)，以及以該化合物等做為有效成分之彈性蛋白酶所參與之各種發炎疾病之治療或預防劑。
