A perfusion system includes a fluid reservoir configured to hold a portion of fluid, the portion of fluid having a volume, the fluid reservoir having a total capacity that is greater than the volume； an imaging device, the imaging device configured to obtain image data corresponding to the fluid reservoir； and a controller. The controller is configured to receive the image data from the imaging device； determine the volume based on the image data； and facilitate control, in response to at least one of a user input and the determined volume of the portion of fluid, of an operating parameter corresponding to the fluid reservoir to facilitate changing or maintaining the volume of the portion of the fluid.
