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DRY POWDER COMPOSITIONS AND METHODS FOR TREATING PULMONARY DISEASES
专利权人:
ПУЛМЭТРИКС; ИНК. (US)
发明人:
СУНГ Джин С. (US),ЛИПП Майкл М. (US)
申请号:
RU2011137960/15
公开号:
RU2011137960A
申请日:
2010.03.26
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. Suitable for inhalation dry powder, including suitable for inhalation of dry particles containing a salt of a divalent metal cation; moreover, the salt of the divalent metal cation provides the presence of a divalent metal cation in an amount equal to about 5% or more by weight of the dry particle, and the dry particles suitable for respiration have a volume median geometric diameter (VMGD) of about 10 μm or less and a dispersibility ratio ( 1/4 bar), measured by laser diffraction (RODOS / HELOS system), less than about 2.0.2. The dry powder suitable for inhalation according to claim 1, characterized in that it has a volume median geometric diameter (VMGD) of about 5.0 μm or less. The dry powder suitable for inhalation according to claim 1, characterized in that it has a dispersibility ratio (1/4 bar), measured by laser diffraction (RODOS / HELOS system), of less than about 1.5.4. A dry powder suitable for inhalation according to claim 1, characterized in that it further comprises a monovalent metal salt, which ensures the presence of a monovalent metal cation in an amount equal to about 6% or more by weight of the particles. The dry powder suitable for inhalation according to claim 1, characterized in that it contains a fine particle fraction (FPF) with a size of less than 5.6 microns in an amount equal to at least 45%. The dry powder suitable for inhalation according to claim 1, characterized in that it contains a fine particle fraction (FPF) with a size of less than 3.4 microns in an amount equal to at least 30%. The dry powder suitable for inhalation according to claim 1, characterized in that it contains a fine particle fraction (FPF) with a size of less than 5.0 microns in an amount equal to at least 45%. Prig�1. Пригодный для вдыхания сухой порошок, включающий пригодные для вдыхания сухие частицы, содержащие соль катиона двухвалентного металла; причем соль катиона двухвалентного металла обеспечивает наличие катиона двухвалентного металла в количестве, равн
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