The invention provides methods and compositions for improving production of exogenous polypeptides in large scale culture of mammalian host cells. The methods and compositions utilize RNA interference to inhibit expression of one or more specific host cell proteins. The present invention is based on the identification of specific mammalian genes and sequences therein that are useful as RNAi targets to enhance the production of exogenous proteins in mammalian cell culture.Linvention concerne des méthodes et des compositions permettant daméliorer la production de polypeptides exogènes dans une culture à grande échelle de cellules hôtes de mammifères. Les procédés et les compositions utilisent linterférence ARN pour inhiber lexpression dune ou de plusieurs protéines spécifiques de cellules hôtes.
