Systems and methods are for analyzing Positron Emission Tomography (PET) image data. The methods may include generating a set of standardized uptake values (SUVs) of global or localized PET data for voxels within a selected region of interest (ROI), normalizing the set of SUVs by generating a set of SUVPs where each corresponding SUVP for each SUV is obtained using the formula: SUVP=(SUV−；M)/S, wherein M corresponds to a peak value for the set of SUVs, and S corresponds to a spread for the set of SUVs, and generating a normalized image based on the set of SUVPs for the ROI. The systems may include any suitable device for PET image analysis performing the methods.
