Mi-Hua Tao,Ho-Yuan Chou,Hsin-Hsin Shen,Tsai-Yu Lin
申请号：
US12858305
公开号：
US20120045511A1
申请日:
2010.08.17
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A thermosensitive hepatitis B vaccine is provided. The thermosensitive hepatitis B vaccine includes an aqueous phase solution comprising a biodegradable thermosensitive hydrogel copolymer； a surface antigen of hepatitis B virus (HBsAg)； and a bioactive substance. The thermosensitive hepatitis B vaccine of the disclosure is particularly suitable for being applied in the patients, which are low responsive or non-responsive to conventional hepatitis B vaccine, for enhancing the induction of cell-mediated immune responses and overcoming the HBsAg non-responsiveness.
