The present invention relates to a new pharmaceutical composition containing nicotinic acid, nicotinamide, tryptophan or related compounds for positively influencing the intestinal microbiota. In certain embodiments, the pharmaceutical composition is partially or entirely released into the small intestine or large intestine.本發明係關於一種含有用於正向影響腸道微生物相之菸鹼酸、菸鹼醯胺、色胺酸或相關化合物的新的藥學組合物。在某些實施例中,該藥學組合物部分或全部釋放在小腸或大腸內。