您的位置: 首页 > 农业专利 > 详情页

DERIVATIVES OF N-HYDROXYAMIDE AND USE OF THE SAME.
专利权人:
MERCK SERONO SA
发明人:
SWINNEN, DOMINIQUE,GONZALEZ, JEROME
申请号:
ES06819550
公开号:
ES2372420T3
申请日:
2006.11.16
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
A derivative of N-hydroxyamide according to formula (I), in which: A is chosen from -C (B) - and N; B is H or B forms a bond with the carbon atom that supports either R 5 or R 7; R 1 is selected from H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, heterocycloalkyl, aryl, heteroaryl, C3-C8 cycloalkyl-C1-C6 alkyl, heterocyclylalkyl-C1-C6 alkyl, heteroaryl-C1-C6 alkyl, amino and alkoxy; R 2 is chosen from H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, heterocycloalkyl, alkoxy, aryl and heteroaryl; R 3 is selected from H, C1-C6 alkyl, C2-C6 alkenyl and C2-C6 alkynyl; R 4, R 5, R 6 and R 7 are independently selected from H, C1-C6 alkyl, C2-C6 alkenyl and C2-C6 alkynyl; or R 4 and R 7 together form a bond -CH2-; n is an integer chosen from 1, 2, 3, 4, 5 and 6; the carbon atoms (2) and (3) are two chiral centers, in which the chiral center (2) has a configuration chosen between "S" and "R" and where the chiral center (3) has a "S" configuration ", as well as its pharmaceutically acceptable salts.Un derivado de la N-hidroxiamida según la fórmula (I), en la que: A se elige entre -C(B)- y N; B es H o B forma un enlace con el átomo de carbono que soporta bien R 5 o bien R 7 ; R 1 se elige entre H, alquilo C1-C6, alquenilo C2-C6, alquinilo C2-C6, cicloalquilo C3-C8, heterocicloalquilo, arilo, heteroarilo, cicloalquil C3-C8-alquilo C1-C6, heterociclalquil-alquilo C1-C6, heteroaril-alquilo C1-C6, amino y alcoxi; R 2 se elige entre H, alquilo C1-C6, alquenilo C2-C6, alquinilo C2-C6, cicloalquilo C3-C8, heterocicloalquilo, alcoxi, arilo y heteroarilo; R 3 se elige entre H, alquilo C1-C6, alquenilo C2-C6 y alquinilo C2-C6; R 4 , R 5 , R 6 y R 7 se eligen independientemente entre H, alquilo C1-C6, alquenilo C2-C6 y alquinilo C2-C6; o R 4 y R 7 forman juntos un enlace -CH2-; n es un número entero elegido entre 1, 2, 3, 4, 5 y 6; los átomos de carbono (2) y (3) son dos centros quirales, en los que el centro quiral (2) tiene una configuración elegida ent
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充