Mark S. F. Clarke,Alamelu Sundaresan,Neal R. Pellis
申请号：
US12781482
公开号：
US08557576B2
申请日:
2010.05.17
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present disclosure provides ex vivo-derived mineralized three-dimensional bone constructs. The bone constructs are obtained by culturing osteoblasts and osteoclast precursors under randomized gravity vector conditions. Preferably, the randomized gravity vector conditions are obtained using a low shear stress rotating bioreactor, such as a High Aspect Ratio Vessel (HARV) culture system. The bone constructs of the disclosure have utility in physiological studies of bone formation and bone function, in drug discovery, and in orthopedics.
