DÉRIVÉS ALCALOÏDES CONTENANT UN ISOQUINOLINE ET LEUR COMPOSITIONS, UTILES DANS LA RÉDUCTION DES TAUX LIPIDIQUES

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专利权人:

CVI PHARMACEUTICALS LIMITED

发明人:

申请号：

EP09775524.3

公开号：

EP2370434B1

申请日:

2009.12.22

申请国别(地区):

EP

年份:

2014

代理人:

摘要：

The present technology relates to compounds of Formulas (V) and methods of making and using such compounds. Methods of use include prevention and treatment of hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, hepatic steatosis, and metabolic syndrome. Compounds disclosed herein also lower total cholesterol, LDL-cholesterol, and triglycerides and increase hepatic LDL receptor expression, inhibit PCSK9 expression, and activate AMP-activated protein kinase.

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