An apparatus (3700) for insertion of a medical device in the skin of a subject is provided, as well as methods of inserting medical devices. Said apparatus includes a sheath (3708), a device support (3730) movable between a proximal and distal position, a sharp support (3716) movable between a proximal and distal position, a handle (3702) movable between a proximal and distal position, and a driver (3746).被験者の皮膚に医療用装置を挿入する装置、および医療用装置を挿入する方法が提供される。