Austin L. Gurney,Timothy Charles Hoey,Maureen Fitch Bruhns,Fumiko Takada Axelrod
申请号：
US14577484
公开号：
US09499613B2
申请日:
2014.12.19
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides an antibody that specifically binds to a non-ligand binding membrane proximal region of the extracellular domain of a human Notch receptor and inhibits tumor growth. The present invention further provides a method of treating cancer, the method comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding membrane proximal region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.
