[6-(5-Ethoxymethoxy-benzofuran-2-yl)-2-nitro-pyridin-3-yl]-methyl-carbamic acid tert-butyl ester, [5-(5-ethoxymethoxybenzofuran-2-yl)-6-nitro-pyridin-2-yl]-methyl-carbamic acid tert-butyl ester and processes for their preparation
BJORK, SETH,DELISSER, VERN,JOHNSTROM, PETER,NILSSON, NILS ANDERS,RUDA, KATINKA,SCHOU, PER MAGNUS,SWAHN, BRITT-MARIE
申请号：
NZ59144609
公开号：
NZ591446A
申请日:
2009.08.28
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed are the compounds [6-(5-ethoxymethoxy-benzofuran-2-yl)-2-nitro-pyridin-3-yl]-methyl-carbamic acid tert-butyl ester and [5-(5-ethoxymethoxy-benzofuran-2-yl)-6-nitro-pyridin-2-yl]-methyl-carbamic acid tert-butyl ester. Further disclosed are crystalline forms of the compounds, processes for their preparation and their use as a synthetic precursor for making labelled compounds, such as those wherein the label is an 18F atom, and particularly wherein said radio isotopically labelled compounds are selected from 2-(6-[18F]-fluoro-5-methylamino-pyridin-2-yl)-benzofuran-5-ol and 2-(2-[18F]-fluoro-6-methylamino-pyridin-3-yl)-benzofuran-5-ol or salts thereof.
