Raymond J. Deshaies;Senthil Radhakrishnan;Candy S. Lee;Jefferson Y. Chan
发明人:
Raymond J. Deshaies,Senthil Radhakrishnan,Candy S. Lee,Jefferson Y. Chan
申请号：
US12941959
公开号：
US09493833B1
申请日:
2010.11.08
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Methods and compositions for inhibiting Nrf1 activity are provided for enhancing apoptosis in mammalian cells. Apoptosis is enhanced in mammalian cells by co-inhibiting Nrf1 activity and proteasome activity. Methods for identifying Nrf1 inhibitors are provided using an assay for screening Nrf1 inhibitors that enhance proteasome inhibition by preventing induced proteasome expression.
