JUNG, SUNG YOUB,WOO, YOUNG EUN,LIM, SE YOUNG,CHOI, IN YOUNG,LEE, JAE HO,KWON, SE CHANG,MOON, SUNG HWAN,LIU, JIAWANG
申请号：
CA2847837
公开号：
CA2847837A1
申请日:
2012.09.05
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present invention relates to an anti-cancer pharmaceutical composition comprising an interferon alpha or a polymer congugate thereof and use thereof in the treatment of cancer by co-administration with anti-cancer agents. The interferon alpha conjugate of the present invention shows a longer in vivo half-life and a more excellent anti-cancer activity than the conventional interferon alpha, and in particular, its co-administration with an anti-cancer agent such as gemcitabine has synergistic inhibitory effects on cancer cell growth and proliferation so as to exhibit a remarkably excellent anti-cancer activity. Further, the anti-cancer pharmaceutical composition of the present invention has excellent in vivo half-life and anti-cancer activity to greatly reduce administration frequency. Co-administration of an anti-cancer agent and the interferon alpha conjugate having excellent anti-cancer activity reduces administration dose of anti-cancer agent so as to reduce side effects of anti-cancer agent and increase treatment compliance of patient.
