PYRROLE DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS SUCH AS ALZHEIMER S AND PARKINSON S DISEASE
Disclosed is a compound of formula (I) wherein a and R R are as described herein as a modulator of nicotinic acetylcholine receptors particularly the a7 subtype in a subject in need thereof as well as analogues prodrugs isotopically substituted analogs metabolites pharmaceutically acceptable salts polymorphs solvates isomers clathrates and co crystal thereofs for use either alone or in combinations with suitable other medicaments and pharmaceutical compositions containing such compounds and analogues. Also disclosed are a process of preparation of the compounds and the intended uses thereof in therapy particularly in the prophylaxis and therapy of disorders such as Alzheimer s disease mild cognitive impairment senile dementia and the like.
