CHARLES KIM,NICHOLAS ROBERT PERL,JOEL MOORE,TAKASHI NAKAI,THOMAS WAI HO LEE,JASON ROHDE
申请号：
ARP110102359
公开号：
AR088020A1
申请日:
2011.06.30
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
The formula compound (1) is described,As a stimulator of GHS, especially as an independent non HME stimulator. Drug synthesis and use Claim 1: a compound calculated according to formula (1),Or a pharmaceutically acceptable salt, in which ring B is a phenyl or a heteromorphic ring of six members containing one or two nitrogen atoms； n is an integer selected from 0 to 3； each JB is selected independently of the halogen； and；an aliphatic C₁₋₆,-Orb or c833238331-8328；wherein each of said C₁₋₆ aliphatic and each of said C₃₋₈ cycloaliphatic group is optionally and independently substituted by up to 3 cases of R³；each RB is independently selected from hydrogen, a C₁₋₆ aliphatic or a C₃₋₈ cycloaliphatic；wherein each of said C₁₋₆ aliphatic and each of said C₃₋₈ cycloaliphatic ring is optionally and independently substituted by up to 3 cases of R³；each R³ is independently selected from halogen, -CN, C₁₋₄-alkyl,haloalkyl C₁₋₄,-O (alquilo C) u -O (haloalquilo C)X is selected from n, c-jd or C-H； or an integer from 0 to 3； each JD is selected independently of halogen.-ORD -SRD -C (O) RD -C (O) ORD -C (O) N (RD)-CN -N (RD)-N (R) C (O) RD -N (R) C (O) ORD -SO RD -SO N (RD)-N (Rᵈ) SO₂RD, an aliphatic C₁₋₆,- (Cif aliphatic) -RD, a C₃₋₈ cycloaliphatic ring,An arilo ring composed of 6 to 10 members, a heteromorphic ring of 4 to 8 members, or a heteromorphic ring of 5 to 10 members； in this heterocyclic ring of 4 to 8 members, each heterocyclic ring of 5 to 10 members is composed of 1 to 3 heteromorphic atoms selected independently of O, n or s； in this ring, each is selected by O, n or S. One of the aquifers is c83321c831832626；Each c833231 ring 8328；There are 6-10 members for each of the 6-10 members of the arilo rings. Among them, the aperiodic rings of 4-8 members can be replaced independently with 5-10 members of the aperiodic rings, and the maximum number of r83099 can be replaced；each RD is independently selected from hydrogen, an aliphatic C₁₋₆,- (alif tico C) -Ra C₃₋₈ cycloali
