A multi-barrel syringe is disclosed for the dual function of delivering and drawing fluid from a target site. The syringe has at least two barrels that may be positioned coaxially relative to one another. One barrel may be pre-filled with sterile delivery fluid designed to irrigate catheter tubing. Another barrel may be provided for removing delivered fluid or other body fluid from a site. The syringe may orientate the barrels such that fluid passing in one barrel does not contact the other barrel. The syringe includes collapsible and extendable plungers for each barrel where each plunger is length adjustable. While in use, the syringe includes a locking mechanism to prevent movement of other plungers while one plunger is in use. Methods of using the described syringe are also provided.
